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Large language models (LLMs) are designed to generate answers to user prompts, which often drives them to respond even when uncertainty is high, information is incomplete, or a refusal would be more appropriate. In healthcare, this tendency can be dangerous: confidently stated but inaccurate medical advice can cause significant harm, making the ability to abstain […]
🔘 Paper page: nature.com/articles/s41586-025-10014-0 Abstract Deep learning models that predict functional genomic measurements from DNA sequences are powerful tools for deciphering the genetic regulatory code. Existing methods involve a trade-off between input sequence length and prediction resolution, thereby limiting their modality scope and performance1,2,3,4,5. We present AlphaGenome, a unified DNA sequence model, which takes as
Advancing regulatory variant effect prediction with AlphaGenome Read More »
Underpinning the latest version of AlphaFold is a novel machine learning approach that incorporates physical and biological knowledge about protein structure, leveraging multi-sequence alignments, into the design of the deep learning algorithm.
Highly accurate protein structure prediction with AlphaFold Read More »
